Effect of Sodium Hyaluronate on Mechanical and Sorption Properties of IPN Hydrogels Based on Acrylic Acid and Acrylamide

EasyChair Preprint no. 1878

Abstract

Acrylic hydrogels are popular medical materials. However, acrylic hydrogels, consisting of a single polymer network, do not have sufficient mechanical characteristics. Modified hydrogels have increased strength and mechanical characteristics, and their sorption properties also change. In this work, IPN hydrogels based on a copolymer of acrylic acid and acrylamide filled with various amounts of sodium hyaluronate and bentonite were synthesized. For these hydrogels, we studied the water sorption capacity and mechanical characteristics: relative elongation at break and tensile strength. It was shown that for hydrogels filled only with bentonite, a nonlinear decrease in the equilibrium moisture absorption and an increase in the concentration of bentonite in the composite is observed. For IPN hydrogel filled with sodium hyaluronate, the characteristic of equilibrium sorption has a maximum of sorption around 0.05 mas.% strength. An increase in the durability of samples modified with both bentonite and sodium hyaluronate is shown. The relative elongation of the samples at the time of rupture for hydrogels with bentonite decreases linearly with increasing concentration of bentonite. The relative elongation at the time of rupture of the samples modified with both bentonite and sodium hyaluronate has a characteristic with a maximum around -of 0.05-0.1 mas.% of sodium hyaluronate.

Keyphrases: Bentonite, human serum albumin, Hydrogels, radical polimerisation, sodium hyaluronat, sorption

@Booklet{EasyChair:1878,
  author = {Tatiana Nosenko and Vera Sitnikova and Maya Uspenskaya},
  title = {Effect of Sodium Hyaluronate on Mechanical and Sorption Properties of IPN Hydrogels Based on Acrylic Acid and Acrylamide},
  howpublished = {EasyChair Preprint no. 1878},

  year = {EasyChair, 2019}}