Predictive Value of Biomarkers for Severe COVID-19 Outcomes: Enhancing Prognostic Assessment in Hospitalized Patients

EasyChair Preprint no. 12885

Abstract

This study investigates the predictive value of biomarkers in determining severe outcomes among hospitalized patients with COVID-19, aiming to enhance prognostic assessment and inform clinical decision-making. A comprehensive analysis was conducted on a cohort of hospitalized SARS-CoV-2 patients, focusing on various biomarkers including inflammatory markers, coagulation factors, and other relevant indicators. Results revealed significant associations between specific biomarkers and the development of severe outcomes, such as intensive care unit (ICU) admission, mechanical ventilation requirement, and mortality. Elevated levels of inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin were consistently linked with poorer prognosis and increased risk of adverse outcomes. Additionally, abnormalities in coagulation parameters including D-dimer and fibrinogen levels were identified as potential predictors of disease severity and mortality. Moreover, certain cardiac biomarkers such as troponin and brain natriuretic peptide (BNP) demonstrated prognostic significance in predicting cardiac complications and mortality risk in COVID-19 patients. Integration of these biomarkers into prognostic models could improve risk stratification and facilitate early identification of patients at higher risk of severe outcomes, enabling timely interventions and personalized management strategies.

Keyphrases: biomarkers, coagulation factors, COVID-19, Inflammatory markers, Intensive Care Unit, mechanical ventilation, Mortality, prognostic assessment, SARS-CoV-2, severe outcomes

@Booklet{EasyChair:12885,
  author = {Battle Hurry},
  title = {Predictive Value of Biomarkers for Severe COVID-19 Outcomes: Enhancing Prognostic Assessment in Hospitalized Patients},
  howpublished = {EasyChair Preprint no. 12885},

  year = {EasyChair, 2024}}